If you are chronically tired, then you should watch this video right now: http://www.howtochangeyourownbatteries.com/go/SAMe In this video I will discuss SAMe Synergy and Interactions Synergy Folic acid, B6 and B12 are synergistic with SAMe for cardiovascular diseases Fish oil or other omega-3 fatty acid sources are synergistic with SAMe for brain health, neurodegeneration and depression Vitamins C and E increase SAMe’s ability to fight oxidative stress Selegiline (also called deprenyl) plus SAMe has been used for Parkinson’s disease Also L-dopa, again for Parkinson’s N-acetyl cysteine (NAC) and acetyl-L-carnitine (ALC) together with SAMe can enhance cognition Interactions: First of all, DO NOT combine SAMe with selective serotonin reuptake inhibitors These are SSRI-antidepressants such as: MAO-A inhibitors or St. John’s Wort DO NOT combine SAMe with dextromethorphan, Meperidine, pentazocine, cyclobenzaprine or tramadol DO NOT combine SAMe with beta blockers In short, DO NOT combine SAMe with any substances which increase serotonin unless monitored by a physician Serotonin levels can be increased: 1) by direct supplementation, 2) By increasing secretion and 3) by decreasing serotonin inactivation Excess serotonin can be fatal That being said, There are NO cases of death or overdosing with SAMe, But you should never exceed 1.6g/day (8x 200mg tablets) By comparison, your body makes about 6-8 grams/day - that’s 30 to 80 SAMe tablets SAMe is comparably free of side effects compared to conventional depression medication It does NOT cause: weight gain, panic attacks or severe gastrointestinal distress Remember that pregnant and breastfeeding women should not take SAMe SAMe should not be combined with Valium, Xanax or other benzodiazepine drugs Alcohol - taking SAMe before binge drinking lowers blood alcohol compared to controls Sidenote A well functioning brain is a happy brain http://www.youtube.com/watch?v=oP8lQJXlfj8